- About Us
- Research & Pipeline
- Investor Centre
- Media Centre
Kazia Therapeutics (ASX: KZA, NASDAQ: KZIA) is developing its lead therapeutic program, GDC-0084, for the deadly brain cancer, glioblastoma multiforme (GBM).
Kazia licensed GDC-0084 in late 2016 from Genentech, a member of the Roche Group, where it had previously completed a phase I clinical study in 47 patients with advanced glioma. Genentech’s phase I study demonstrated a favourable safety profile and provided signals of efficacy. Genentech also conducted an extensive preclinical program which showed encouraging results for GDC-0084 in animal models of glioblastoma.
An international phase II clinical trial of GDC-0084 was initiated in the US today, with Australian sites to open in 2019.
In this interview led by NDF Research’s Senior Analyst, Stuart Roberts, Kazia Therapeutics CEO and Executive Director Dr James Garner talks about:
On the study’s adaptive design and targeting newly diagnosed patients identified as non-responders to the existing treatment, temozolomide, Dr Garner says:
“It gives us the opportunity to position our drug in a head to head setting against an approved standard of care.”
“There really hasn't been much progress in the treatment of glioblastoma for 15 or 20 years,” Dr Garner says.
“The current treatment paradigm is that patients receive surgery, they receive radiotherapy and then they go on temozolomide, a drug that has been around for some time and definitely works - but it only works for about one third of the patients. For the other two thirds of patients, there really is no generally accepted pharmacological therapy that offers benefits, and that’s the gap we're trying to fill with GDC-0084.
“GDC-0084 is an unusual drug because it was developed from the ground up as a brain cancer drug. Most of the drugs that have come to glioblastoma have really been breast cancer drugs or lung cancer drugs, where the company is trying to test them out in brain cancer. Genentech approached this very differently – they started out with a blank sheet of paper and asked: how do we make it great drug for glioblastoma?”